Yerram Sai Rama Krishna Reddy*


The first cases of FOP were described by Patin in 1692 and by Freke in 1739. In 1918, Rosenstirn conducted an extensive review of the medical literature, describing 115 cases of FOP. The disease was first named myositis ossificans progressiva, meaning a muscular inflammation that gradually turned into bones. However, this process affects not only muscles, but also soft parts such as articular capsules and ligaments.Thus, the name was changed to fibrodysplasia ossificans progressiva by Victor McKusick in 1970 Fibrodysplasia ossificans progressiva affects only one in every 2 million peopleworldwide, according to the U.S. National Institutes of Health (NIH). The International FOP Association says there are 800 confirmed cases across the globe, 285 of them in the United States. The genetic defect in this disorder has not been characterized in Indian patients till date.

Keywords: FOP- Fibrodysplasia ossificans progressive, ACVR1 - activin-like kinase 2 (ALK2), Glitch- a sudden malfunction or fault, Desmoid Tumor - an abnormal growth that arises from connective tissue.

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