Abstract
STATINS: BEYOND CHOLESTEROL LOWERING

Dr. Sushil Kiran Kunder, Dr. Navin Patil*, Dr. A. Avinash, Dr. Anurag Pathak, Dr. Avin S, Dr. Shalini Adiga

ABSTRACT

Statins are most commonly prescribed drugs worldwide as cholesterol lowering agents. Several observational studies have shown multi-faceted action in different pathological conditions by acting through cholesterol dependent as well as cholesterol independent mechanisms which affect several tissue functions. The end result is modulation of specific signal transduction pathways suggesting the ability of statins to exert pleiotropy. Pleiotropic effects or cholesterol independent effects include anti-inflammatory effects, immunomodulation, plaque stabilizing effects, anti-thrombotic, antiplatelet effects and role in vascular dysfunction. Majority of these roles are due to inhibition of a process called isoprenylation thereby preventing activation of small GTPases which are pro inflammatory signaling molecules. Here is a review of pleiotropic effects of statin therapy and their role in non-cardiac diseases.

Keywords: Pleiotropy, isoprenylation, antioxidant, plaque-stabilizing, nitric oxide.


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