Abstract
COMPARATIVE EFFICACY STUDY OF A POLYHERBAL FORMULATION WITH OTHER AVAILABLE DRUGS IN PROPIOBACTERIUM ACNES INDUCED RAT MODEL

Ashok Kumar*, Nasim Mansoori, KavitaMunjal, Geetanjali Dahiya, Vivek Dwivedi and Manu Choudhary

ABSTRACT

Introduction: Propionibacterium acnes (P. acnes) is a commensal anaerobic, Gram positive bacteria playing an important role in the pathogenesis of various skin infections and diseases. The study evaluated the efficacy of a polyherbal formulation and compared with various marketed anti acne formulation in P. acnes induced acne in albino wistar female rats. Biochemical and enzymatic parameters were studied and histopathology of ear pinna tissue was done in acne exposed rats. Materials and Methods: 48 rats were distributed in eight groups containing six rats in each group. Group I: Control (saline treated), Group II: P. acne induced group (diseases control), Group III: P. acne induced group (polyherbal formulation treated) and group IV, V, VI, VII, VIII: P. acne induced group (marketed drug A, B, C, D, and E treated). Results: Present finding showed that activities of antioxidant enzymes were significantly decreased along with increased level of MDA in untreated group at 10th day (induction period) and 30th day (treatment period) of the study. Similarly, the level of total protein, Albumin and cholesterol were also found to be significantly increased along with decreased level of triglyceride in untreated group at 10th day. These biochemical parameters were significantly improved at 30thday. Conclusion: After treatment antioxidant enzymes (SOD, Catalase) along with MDA, improved significantly and normalized intestinally, we observed that polyherbal formulation have an antiseptic and antibacterial property that may be beneficial for human who suffer from chronic Acne Vulgaris.

Keywords: Polyherbal; topical drug; antimicrobial; anti-inflammatory; antiseptic properties.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2022 Issue has been successfully launched on 1 NOVEMBER 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT