375 SYNTHESIS, CHARACTERIZATION, DOCKING, ANTICANCER AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE LIGAND DERIVED FROM SALICYLALDEHYDE AND ITS NICKEL (II) COMPLEX
A. P. Arumugam, G. Elango and S. Guhanathan*
ABSTRACT
A new series of Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from Vanillin and acetoacetanilide with ethylenediamine has been synthesized. A new series of Ni(II) complex of the Schiff base derived from salicylaldehyde and 3,4-diaminobenzophenone with acetyl acetone have been synthesized. These compound have been characterized by molar conductivity measurements, infrared, electronic spectra. The Schiff base ligand and its complex further identified by 1H NMR, 13C NMR and molecular docking study. The anticancer potential of the Nickel (II) complex was determined against A549 lung cancer cells, they exhibited appreciable anticancer activity. The in vitro cytotoxicity of the complex was examined against cancer cell line by MTT assay. The Schiff base Ni(II) complex was tested its cytotoxicity and found that the 50 percentage of activity inhibitory concentration (IC50) value around 40.47 percentage in 1000 μg/ml. Antimicrobial activity of the Schiff base ligand and their metal complex reveals that the Schiff base transition metal complex show significant activity against some bacteria. model and EAC cell induced ascites tumour model were mainly used for antitumor studies. Copper complex administrated at different concentrations in Swiss albino mice to access increases in the survival rate and the life span of Ascites tumour enduring mice in a concentration dependent manner. Antimicrobial activities of the Schiff base ligand and their metal complexes reveals that the Schiff base transition metal complexes show significant activity against some fungi and bacteria.
Keywords: Docking study, anticancer activity and antimicrobial activity.
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