Abstract
ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF MORINDA CITRIFOLIA ROOT EXTRACTS

Dr. Ranju Pal* and Dr. Manoj Pandey

ABSTRACT

The study was designed to evaluate the anti-inflammatory and analgesic activities of ethanolic extract of roots of Morinda citrifolia Linn. (Rubiaceae). The anti-inflammatory potential of ethanolic extract has been determined by using carrageenan-induced paw edema assay in albino rats. The analgesic activity was tested by using acetic acid- induced writhing response and hot plate method in albino mice. The administration of extract at doses of 100 and 200 mg/kg, by oral administration, significantly inhibited carrageenan- induced inflammation. Also, the acute treatment of extract produced a significant antinociceptive effect in the acetic acid-induced writhing, and hot-plate-induced pain. The experimental data demonstrated that ethanolic extract of roots of Morinda citrifolia Linn. possess remarkable anti-inflammatory and analgesic activities.

Keywords: Morinda citrifolia, antinociceptive, Rubiaceae.


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