EVALUATION OF ANTIGOUT ACTIVITY OF BRYOPHYLLUM CALYCINUM LEAVES EXTRACTS ON POTASSIUM OXONATE-INDUCED GOUT RAT MODEL
Eakta Kandpal* and Priyanka Bhatt
ABSTRACT
Objective: The present study has been conducted to evaluate antigout activity of aqueous and alcoholic extracts of Bryophyllum calycinum leaves on potassium oxonate-induced gout rat model. Method: The study was conducted on Sprague-Dawely rats dividing them in eight groups having six rats in each group. Rats were fasted for 16 hr before potassium oxonate injection. After 1 hr. of Oxonate injection, blood samples were collected for parameter evaluation for control group. Allopurinol was given to the standard group and different test extract, each extract with three different doses i.e. 100, 150, 200 mg/kg were given to treated groups T1,T2,T3,T4,T5 for consecutive 5 days. Blood samples were taken on 5th day for evaluation of anti gout activity of test extracts of Bryophyllum calycinum. Results for parameter evaluated for treated groups were compared with standard group. Results: At the end of study, rats of gout control group showed increase in platelets counts, serum creatinine, uric acid, blood urea nitrogen (BUN), and xanthine oxidase (XO) enzyme level along with alterations in kidney tissues as compared to vehicle control group. Gouty rats treated with aqueous and alcoholic extracts of Bryophyllum calycinum at 200 and 400 mg/kg body weight and standard treatment Allopurinol at 5 mg/kg body weight showed reduction in platelets counts, serum creatinine, and uric acid, BUN, and XO enzyme level. Conclusion: Oral administration of aqueous and alcoholic extracts of Bryophyllum calycinum leaves has shown protection against gout in dose-dependent manner in rats.
Keywords: Bryophyllum calycinum, Anti gout activity, Hyperuriceamia, Allopurinol.
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