European Journal of Biomedical and Pharmaceutical Sciences

PHENYTOIN INDUCED PARKINSONISM: A RARE CASE REPORT

Shaik Kareemulla, Chandana T.*, A. V. Kavyasree and M. Prashanth

ABSTRACT

Anti-epileptic drugs cause diverse adverse effects of cognitive impairment, skin reactions and teratogenic effects of offspring in pregnant population and metabolic alterations due to enzyme induction. Majority of these reactions are being reported and extensively monitored for better patient compliance. In contrast the motor adverse effects of AEDs’ have not become recognised as a serious adverse event of AEDs’. Drug Induced Parkinsonism is one among the motor disorders that are caused by chronic usage of AEDs’. An elaborated literature search had disclosed that very few reports of phenytoin induced Parkisnsonism were published and in this scarcity, we report a case of 26 year old male patient who developed Parkinsonism after chronic treatment with phenytoin. After discontinuation of the culprit drug the symptoms were improved and another AED was added to the regimen.

Keywords: AED, DIP, Movement Disorders, Parkinson Disorder (PD).