Abstract
REVIEW ON DRUG INTERACTIONS OF ALPRAZOLAM ON PHARMACODYNAMIC AND PHARMCOKINETIC ACTIONS

Talluri Chakradhar and Sumanta Mondal*

ABSTRACT

Alprazolam is the one of the mostly prescribed benzodiazepines in the all over the world. It is commonly regarded as a safe and efficient drug for the treatment of anxiety disorders and panic disorders. Some overdoses that are due to the sole ingestion of alprazolam has been reported. The paper documents is a fatality due to alprazolam intoxication & describes the distribution of alprazolam and an active metabolite, (x-hydroxyalprazolam, in tissues obtained at autopsy. Qualitative identification of the drugs is achieved by full-scan mass spectroscopy and gas-chromatograaphy, and quantitative analysis was performed by high-performance liquid chromatography. High concentrations of alprazolam are found in all specimens analyzed, but the metabolite was detected only in subclavian blood, urine, bile, and liver. heart blood alprazolam concentration of 2.1 mg/t is the highest reported in the postmortan.

Keywords: x-hydroxyalprazolam, subclavian blood, urine, bile, and liver.


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