European Journal of Biomedical and Pharmaceutical Sciences

A SHORT REVIEW OF MATRIX METALLOPROTEINASE – 9

*Dr. Venkatesh Kulkarni and Dr. Praveena Kulkarni

ABSTRACT

Matrix metalloproteinases (MMPs) are group of zinc-dependent peptidases molecule. These are capable of degrading all extracellular matrix. MMPs help in process a variety of non-ECM substrates. They are responsible for physiological and pathological tissue remodeling. MMP-9 belongs to the gelatinase subgroup of MMPs. MMP-9 are involved in tissue growth and morphogenesis. MMP-9 activity is required during embryological development and maintenance of physiology, help in cell migration, modulation of the activity. Various experimental cell line and clinical studies have implicated role of MMP9 in many human diseases including respiratory diseases, cardiovascular disorders, neuropsychiatric disorder, autoimmune diseases, and cancer. This article highlight the nature MMP-9, including chemical structure, genes involved in formation, role in physiological function and role in various diseases including respiratory, cardiovascular and cancer.

Keywords: Matrix metalloproteinases (MMPs),