European Journal of Biomedical and Pharmaceutical Sciences

OVARIAN SERTOLI-LEYDIG CELL TUMOR: REPORT OF A RARE CASE

Hartono Tjahjadi, Laurencia Leny Kurnianingrum and Kusmardi Kusmardi*

ABSTRACT

Ovarian Sertoli-Leydig cell tumors (SLCT) are extremely rare ovarian tumors belonging to the group of sex cord-stromal tumors and divided into four subtypes, that are well differentiated, moderately differentiated, poorly differentiated, and retiform. They are accounting for less than 0.5% of all primary ovarian neoplasms. Ovarian SLCT often diagnosed at early stage with low-malignant behavior. Accurate diagnosis is very important to determine the management. Due to its rarity, ovarian SLCT have low index of suspicion to be diagnosed. Most of ovarian SLCT are unilateral and presented at young women. Mostly the symptoms are presented with lower abdominal or pelvic mass and often come with virilisation due to androgen production. In the case of moderately and poorly differentiated, sometimes will be found heterologous elements. The presence of heterologous elements or retiform pattern being a bad prognostic feature. Immunohistochemistry staining can be utilized to distinguish ovarian SLCT with other resembling entities.

Keywords: Sex cord-stromal tumor, ovarian Sertoli-Leydig cell tumor, well-diferentiated ovarian Sertoli-Leydig cell tumor, rare ovarian tumors.