European Journal of Biomedical and Pharmaceutical Sciences

ANTIBACTERIAL ACTIVITY FROM ETHANOLIC EXTRACT KARAS (AQUILARIA SP.) LEAVES AGAINST PATHOGENIC BACTERIA

Rafika Sari*, Eka Kartika and Pratiwi Apridamayanti

ABSTRACT

Aquilaria microcarpa Baill. and Aquilaria malacanecis Lamk. are group of gaharu producing plants species that are widely cultivated in Indonesia, especially in West Borneo. Based on the empirical data the Aquilaria sp. leaves are usually used to treat the wound in the skin area. The purpose of this research is to determine the Minimum Inhibitory Concentration (MIC) value from ethanol extract of the leaves by disc diffusion technique. The results showed that the MIC value of ethanol extract of Aquilaria microcarpa Baill. Leaves to Staphylococcus aureus and Bacillus cereus bacteria were 1 mg/mL, while MIC values against Staphyloccus epidermidis, Pseudomonas aeruginosa, Bacillus subtilis and Escherichia coli were 1,25 mg/ mL, lastly on Salmonella typhi and Proteus mirabilis were 10 mg/mL. Then, Aquilaria malacancis showed that MIC value against all pathogenic bacteria were 1,25 mg/ml. The conclusion of this research was that Aquilaria microcarpa Baill and Aquilaria malacencis Lamk have potencial antibacterial activity against Gram positive bacteria and Gram negative bacteria.

Keywords: Aquilaria microcarpa Baill., Aquilaria malacanecis Lamk, MIC, Ethanolic extract.