European Journal of Biomedical and Pharmaceutical Sciences

ANTIBIOTIC SENSITIVITY PROFILES AGAINST BACTERIA ISOLATES WHICH INFECTING PATIENTS WITH DIABETIC FOOT ULCERS LEVEL 3 AND 4 WAGNER IN PONTIANAK

Pratiwi Apridamayanti* and Rafika Sari

ABSTRACT

Diabetic foot ulcer is one of many complications of diabetes. This ulcer can lead to wound infection which happens when a patient has high level of blood glucose. Antibiotic is usually prescribed for diabetic foot ulcer patient to prevent the infection and accelerate the wound healing process. Hence, a potent antibiotic is needed. The aim of this research was to determine the profile of antibiotic sensitivity test against bacteria isolates from patients. The isolates were taken in Kitamura clinic in Pontianak in the year of 2015. Level of sensitivity test was determined from the inhibition zone of certain antibiotic against bacteria cultures from patients’ isolates. The result of sensitivity test conducted on Staphylococcus epidermidis and Pseudomonas putida was 89%, Micrococcus luteus and Enterobacter cloacae was 55%, Proteus mirabilis was 42.8%, Proteus vulgaris was 33%, and Proteus retgeri, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus haemolyticus and Escherichia coli was 11%. The result of the antibiotics sensitivity test was analyzed using One-way ANOVA followed by Tukey Post Hoc test. Result of statistical analysis shows From this statistic result that Ceftriaxon, Cefotaxim, Ciprofloxacin, Meropenem, Piperacillin-sulbaktam, Imipenem, and Amicasin were sensitive to patients’ isolates, while Cefadroxil (72.70%) and ; Clindamycin (100%) resistance to patient isolates DFU.

Keywords: antibiotic sensitivity, diabetic foot ulcer (DFU), resistance, Pontianak.