European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF SIMVASTATIN LOADED POLYMERIC NANOPARTICLES

E. Priyanka* and Dr. P. Tripura Sundari

ABSTRACT

AIM:-To formulate and evaluate polymeric nanoparticles of simvastatin. The aim of the present study is to formulate and evaluate polymeric nanoparticles of simvastatin. Simvastatin is used as Anti -Hyperlipidemic agent. It is chemically 3-hydroxy-3-methylglutaryl (HMG) coenzyme A reductase. It has poor solubility and 5% bioavailability. It belongs to BCS Class-II. In the present work attempts were made to prepare polymeric nanoparticles of simvastatin with 12hrs drug release rates. The nanoparticles were prepared by employing Gelatin and sodium alginate as polymers. Gelatin and Sodium alginate is naturally occurring polymer.Tween-80 and span-80 were used as hydrophilic and lipophilic surfactant respectively. Different formulations were prepared at different ratios of polymer and surfactant. The prepared at different ratios of polymer and surfactant. The prepared formulations were coded as (G1-G5) with Gelatin and (S1-S6) with Sodium alginate. All the prepared formulations were analyzed for entrapment efficiency, drug content, microscopic examination and drug release studies. By comparing the results of all formulations,G2 was found to have 88.58% drug content, 79.46% entrapment efficiency and the In-vitro release was found to be 64% and S5 was found to have 75.04% entrapment efficiency, 92.89% drug content and 68% drug release in 12hrs.

Keywords: Simvastatin, Anti-hyperlipidemic agent, Polymeric nanoparticles, Gelatin, sodium alginate, surfactants.