European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS OF IMIDAZOLE DERIVATIVES OF ARYL SUBSTITUTED 1,3-THIAZOLES AND THEIR NANOPARTICLES WITH SPECIAL REFERENCE TO PLANT PATHOGENS OF SOME VEGETABLE CROPS

Chhaya D. Badnakhe* and P. R. Rajput

ABSTRACT

The synthesis, spectral analysis and biological activities of 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-(3N-phenyl)-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (F”) have been carried out. In this case 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-diphenyl-amino-1,3-thiazole (F), 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-(N-phenyl)-[(2-hydroxy-3,5-dichlorophenyl)ethanonylamino]-1,3-thiazole (F’) & 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-(3N-phenyl)-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (F’’) have been screened. The compounds (F), and was synthesized from 1-( 2’- hydroxy-3’ ,5’-dichlor ophenyl)-2-bromo-3-(4”-nitrophenyl)-1,3 propanedione (a4) by the action of diphenyl thiourea, while (F’’) was synthesized from (F) by reaction with α-bromo,2-hydroxy-3,5 dichloroacetophenone to get 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2(N-phenyl)-[(2-hydroxy-3,5-dichlorophenyl)ethanonylamino]-1,3-thiazole (F’). Further (F’) on treatment with KSCN was dissolved in acetic acid gave (F’’). The nanoparticles of the compounds F, F’and F’’ have been prepared by using ultrasonic technique. The titled compounds and their nanoparticles were assayed for antipathogenic impact against some common crop pathogens viz - Aspergillus niger, Pseudomonas lachrymans, Fusarium oxysporum and Fusarium solani.

Keywords: Chalcone, thiazine, diphenyl thiourea, ?-bromo,2-hydroxy-3,5 dichloroacetophenone , KSCN was dissolved in acetic, antipathogenic activities.