European Journal of Biomedical and Pharmaceutical Sciences

“TO STUDY THE EFFECT OF SINGLE DOSE ANTIBIOTIC PROPHYLAXIS VERSUS CONVENTIONAL ANTIBIOTIC THERAPY IN ELECTIVE CASE OF CLEAN SURGERY”

*Dr. Md. Shahabuddin and Dr. Y. R. Lamture

ABSTRACT

Introduction: Antibacterial drugs are considered as powerful tools to prevent infections in different settings. Various analysis which have been done on the antibiotic choice and timing of antibiotics have agreed that first dose of the antibiotic has to be given half- one hour before surgery, and also that a long acting antibiotic is preferred. The conventional use of antibiotics for prolonged period often result in high cost to the patient, hence our intention is to study the effect of single dose prophylactic antibiotic an hour before a surgical intervention with the chosen standard antibiotic with regard to the conventional use of same antibiotics for 3 days. Aims and Objectives: Aim: Study the effect of single-dose antibiotic prophylaxis versus conventional antibiotic therapy in elective cases of clean surgeries. Objectives 1. To evaluate Southampton wound grading system in single dose antibiotic group 2. To evaluate Southampton wound grading system in conventional dose antibiotic group 3. To compare the cost of antibiotic in both these group Material and Method: A study was prospective type and was done in the Surgery Department, JNMC and the patients were randomly assigned into group 1 and group 2. Group 1 is defined as the single dose antibiotic group Group 2 is defined as the conventional dose antibiotic group. Discussion: Antibiotic therapy is administered to the surgical patient to prevent post- operative wound infection. In order to decrease post-operative infection, the antibiotics have been used over-zealously, resulting in increasing incidence of antibiotic resistance and additional burden of cost in the path of recovery of the patient. In the present study, only clean procedures were included, that means wound is not contaminated by flora of the viscera. Hence, to cover the contamination by skin commensals, cephalosporin was used. Present study includes 100 patients and divided into two groups consisting of 50 patients each. The patients who were given single dose antibiotic prophylaxis were included in group 1 and those given conventional therapy of antibiotics were included in group 2.

Keywords: Conventional antibiotic therapy, single dose antibiotic, post operative infection, Southampton grading.