Abstract
VALIDATED AUC METHOD FOR THE SPECTROPHOTOMETRIC ESTIMATION OF RIFAXIMIN TABLET

Srinidhi B. S.*, C. Jose Gnana Babu, Tamizh Mani T.

ABSTRACT

A novel, simple, accurate and precise Area under curve spectroscopic method was developed and validated for the estimation of Rifaximin in bulk and Pharmaceutical dosage forms and AUC was measured at 230-240nm in Methanol : Acetonitrile (60:40). The Linearity was found to be in the concentration range of 5-30 μg/ml and the correlation coefficient was found to be 0.9992 and it has showed good linearity, reproducibility, precision in this concentration range. The regression equation was found to be Y = 0.0245 X + 0.007. The % recovery values were found to be within 98.74-100.8 % showed that the method was accurate. The LOD and LOQ were found to be 0.2138 and 0.6414 μg/ ml, respectively. The % RSD values were less than 2. The present methods is accomplish the validation parameters according to ICH guidelines. The developed method was successfully applied for the quantitative estimation of Rifaximin in bulk and pharmaceutical dosage forms.

Keywords: Rifaximin, Area Under Curve Spectroscopy, Methanol: Acetonitrile (60:40), Linearity, Precision, Ruggedness, Accuracy.


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