European Journal of Biomedical and Pharmaceutical Sciences

ASSOCIATION OF PROSTATE SPECIFIC ANTIGEN LEVELS WITH POSITIVE BONE SCANS

Anurudda Udaya Bandara Pethiyagoda* and Kalyani Pethiyagoda

ABSTRACT

Introduction: Prostate cancer has become a common problem among men around the world. This study was conducted to determine the clinical profiles of patients for whose bone scanning could be eliminated due to a low probability of bone metastasis. Materials and Methods: This retrospective study was conducted among 56 patients who were newly diagnosed with prostate carcinoma at single tertiary referral centre in 2017 and 2018. All subjects had serum prostate specific antigen (PSA) levels, trans-rectal ultrasound guided prostate biopsies and bone scans within 3 months of one another. Statistical analyses were performed using chi-square test and level of statistical significance was considered as p< 0.05 for all analysis. Results: Bone scan was positive in 55.35% and negative in 44.64% patients. Of the 31 positive cases, 9.6% had PSA < 20 ng/ml. Majority (51.61%) of the patients with PSA > 100 ng/ml had multiple skeletal metastases. Of the 25 negative cases, 40% had PSA > 100 ng/ml. Of the 8 patients with serum PSA < 20 ng/ml, 3 patients showed bony metastasis. Conclusions: There is no significant association between bone scans and PSA levels. Therefore, as indicated in international literature we cannot assume, there will be bone deposits if the PSA level more than 20ng/ml.

Keywords: Bone scan, metastasis, prostate carcinoma, PSA.