European Journal of Biomedical and Pharmaceutical Sciences

IN VITRO ANTIMICROBIAL ACTIVITY SCREENING OF HELIOTROPIUM EUROPAEUM AGAINST WIDE RANGE OF MICROORGANISMS AND MULTI DRUG RESISTANT (MDR) BACTERIA

*Mustafa Eray Bozyel, Merve Senturan, Atakan Benek, Elif Merdamert Bozyel, Kerem Canli and Ergin Murat Altuner

ABSTRACT

Since ancient times several diseases have been treated with natural products, such as plants. Heliotropium europaeum L., commonly known as Akrepotu, is an important taxa of the Boraginaceae family. There are antimicrobial researches about H. europaeum in the literature and results are promising. Therefore this medical plant investigated against 41 microorganisms by using disk diffusion method according to show its antimicrobial potential more clearly. A wide range of Gram positive and Gram negative bacteria and yeast were selected to test the antimicrobial effect of H. europaeum. Most of these strains are standard and MDR, some of the strains are clinic isolated and the rest are food isolated. These microbial species are Bacillus subtilis DSMZ 1971, Candida albicans DSMZ 1386, Enterobacter aerogenes ATCC 13048, Enterococcus faecalis ATCC 29212, Esherichia coli ATCC 25922, Listeria monocytogenes ATCC 7644, Pseudomonas aeruginosa DSM 5071, Pseudomonas fluorescens P1, Salmonella enteritidis ATCC 13076, Salmonella typhimurium SL 1344, Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis DSMZ, E. coli (MDR), K. pneumonia (MDR), A.baumannii (MDR), E. aerogenes (MDR), S. odorifera (MDR), P. vulgaris (MDR), S. pneumonia (MDR), S. aureus MRSA, S. aureus MRSA+MDR, P. rustigianii (MDR), A. species (MDR), Staphylococcus hominis (CI), Staphylococcus haemolyticus (CI), Staphylococcus lugdunensis (CI), Shigella boydi (CI), Acinetobacter boumanii (CI), Shigella flexneri (CI), Staphylococcus aureus (CI), Enterococcus faecalis (CI), Klebsiella pneumoniae (CI), Candida tropicalis (CI), Enterococcus durans (FI), Enterococcus faecium (FI), Klebsiella pneumoniae (FI), Listeria innocua (FI), Salmonella infantis (FI), Salmonella kentucky (FI), Esherichia coli (FI), Staphylococcus aureus (FI). The results were presented that H. europaeum ethanol extract has antimicrobial activity against some tested microbial strains.

Keywords: Heliotropium europaeum, antimicrobial activity, MDR, disc diffusion method, ethanol extract.