AN OVERVIEW ON POLYMER GRAFTING
Mayuri Baruah*, Nirju Rani Patar, Koushik Sen Gupta and Biplab Kumar Dey
ABSTRACT
Polymers play a major role in pharmaceutical science as it constitutes an important class of materials by providing suitable substitute for conventional materials. Polymer grafting is a versatile method to modify the polymers in where monomers are covalently bonded to polymer. Recently, this approach open a new opening to pharmaceutical formulation. There are different techniques such as crosslinking, grafting, blending and composite formation techniques are used to modify the polymer. But the selection of proper polymer is a very important step for the formulation of the dosage form. Polymer used in pharmaceutical formulation determine the stability of formulation and drug itself, rate of drug release as well as its mechanism. Natural polymer and fibers are of large use for the mankind. Now a days the whole world has concentrated attention of its activity towards renewable and sustainable resources because of environment as well as health concerns. The use of grafted polymer provide many applications in terms of physicochemical properties as well as drug carrying capacity based on dosage form modifications. This review highlights the basic concept of polymer grafting and its various techniques such as chemical grafting, radiation grafting etc. are discussed with their significant pharmaceutical applications.
Keywords: Polymer, Monomer, Fiber, Grafting, Modification.
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