European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT OF NOVEL PROCESS FOR SYNTHESIS OF 2-PHENYL-4H-3,1-BENZOXAZIN-4-ONE THROUGH MICROWAVE SYNTHESIZER

Kumar Pratyush*, Alpana Asnani and Dinesh Chaple

ABSTRACT

The microwave assisted synthesis approaches comply to all 12 principles of green chemistry. The enhanced penetration power of microwaves are supposed to be the main troubleshooter in field of synthetic chemistry. The Quality by Design (QbD) approach has been used by several formulation chemist but we implemented this approach in synthetic chemistry. The novel proposed method was firstly developed using Quality by Design approach and then the method was improvised for wet lab synthesis. The statistical validation of the method was and finally spectral analysis confirmed the structure of the synthetic compound. The validation of the proposed method was carried out and these validated batches were simultaneously compared with the conventional procedure for synthesis of 2-phenyl-4H-3,1-benzoxazin-4-one. The results of the spectral data, validation and comparison showed that the proposed method was more economical than that of conventional method and also followed green approaches.

Keywords: Microwave assisted synthesis, Quality by Design (QbD), benzoxazinones.