A REVIEW ON IMMEDIATE RELEASE SOLID ORAL DOSAGE FORMS AND STABILITY MONITORING OF FINISHED PRODUCT
Dr. K. Ramesh* and Dr. M. Ganesh
ABSTRACT
Among all the different routes of administration, Oral route of administration has been the preferred and the most widespread route of drug delivery system around the globe. The attractiveness of this dosage form is due to its easy of manufacturing, simplicity of administration, avoidance of pain and good patient compliance. From the perspective of the drug development and formulations, solid dosage form offers better stability as compared to suspension and liquid dosage forms. Hence, most of the NCEs under the development are preferred to formulate into solid dosage forms, which can produce an effective and reproducible in vivo plasma concentration after oral administration. Sometimes immediate onset of action is considered necessary for which immediate release tablets / capsules are the ultimate option. In the present review, it is focused on Ideal Properties Immediate release dosage forms, disadvantages, salient features, Unsuitable drug characteristics, common manufacturing methods, commonly used raw materials, evaluation of powder blend, tablets and capsules, tests in specifications, storage conditions and stability monitoring.
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