Abstract
"THE POSSIBLE PROTECTIVE EFFECT OF OMEGA-3 AGAINST METOCLOPRAMIDE INDUCED HYPERLIPIDEMIA IN RATS"

*Esraa A. Ahmed

ABSTRACT

Metoclopramide (MCA) is one of prokinetic drugs. It is used for the treatment upper gastrointestinal motility disorders such as diabetic gastroparesis, nausea, vomiting and gastroesophageal reflux. It increases serum prolactin level that elevates lipid profile especially triglyceride level. Omega−3 fatty acids are polyunsaturated fatty acids that important for normal physiology and metabolism. It is effective treatment for patients with hypertriglyceridemia at recommended doses. The present study aimed to evaluate the possible protective effect of omega-3 in treatment of MCA-induced hypertriglyceridemia in rats. Hyperlipidemia and hyperprolactinemia was evaluated using biochemical examinations. In this study, MCA treated group showed highly significant elevation in serum prolactin and triglyceride (TG) levels. The levels of total cholesterol (TC) and low density lipoproteins (LDL) were significantly increased compared to both control and co-treated groups with omega-3. However, the high density lipoprotein was decreased significantly in MCA treated rats. Conclusion, these results suggest that omega-3 has a marked protective and therapeutic effect against MCA hyperlipidemia.

Keywords: Dyslipidemias, metoclopramide, omega-3 fatty acids, total cholesterol, triglycerides, low density lipoproteins, high density lipoproteins.


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