European Journal of Biomedical and Pharmaceutical Sciences

THE EFFECT OF THE COMPARISON FROM CONCENTRATION OF KELULUT HONEY (HETEROTRIGONA ITAMA) AND ADEPS LANAE TO THE PHYSICAL STABILITY OF OINTMENT

Wintari Taurina*, Mohamad Andrie and Nurul Fikri

ABSTRACT

Kelulut honey is a natural ingredient that has many benefits and relatively safe. One of the benefits is its regeneration process so it’s useful in healing wounds. The result of research on the inhibition of 5% honey in DMSO shows that it can inhibit Staphylococcus Aureus and Pseudomonas Aeruginosae bacteria. The Ointment is a semisolid medicine that is soft, easy to apply, and is used as an external medicine on skin and mucous membranes. This study aims to find out how the physical stability of adeps lanae-based ointment combined with the active ingredient of kelulut honey (Heterotrigona Itama) and to determine the concentration of adeps lanae base which provides the best physical stability of honey ointment (Heterotrigona Itama). The ointment of kelulut honey was formulated using adeps lanae-based made with three variations in the ratio of active substances, namely F1 50%, F2 60%, and F3 70%, and tested for the stability of physical properties including organoleptic test and homogeneity, spread power test, sticky power test, and the protection power test was then analyzed statistically using SPSS. The ANOVA test results on dispersion and adhesion of ointment showed that there were no significant differences between F1, F2, F3 seen from sig (p> 0.05), and based on the results of the posthoc test the most stable formula was at 70% concentration ointment. The test results on physical stability indicate that all formulas have good physical stability and are able to provide protection against the skin.

Keywords: Ointment, Heterotrigona Itama, Adeps Lanae, Physical Stability.