MOUTH DISSOLVING FILMS: AN EFFECTIVE ORAL DISINTEGRATING DRUG DELIVERY SYSTEM
Venkateswara Rao S.*, Bhavya G. and Padmalatha K.
ABSTRACT
The drug discovery and development of new chemical entity is not only an expensive but also time consuming affair. Hence the pharmaceutical industries are focusing on designing and development of innovative drug delivery systems for the existing drugs. One of such delivery systems is mouth dissolving film, which has gained the popularity among the pediatric and geriatric patients. This mouth dissolving film with many potential benefits of a fast disintegrating tablet but devoid of friability and risk of choking is more acceptable to pediatric and geriatric patients. In view of the advantages of the mouth dissolving films over the fast disintegrating tablets and other dosage forms, it has the potential for commercial exploitation. Formulation of mouth dissolving film can be achieved by various techniques, but the common methods of preparation include spraying and casting. These techniques use hydrophilic film former in combination with suitable excipients, which allow the film to disintegrate or dissolve quickly in the mouth within a few seconds without the administration of water. The oral disintegrating films not only have certain advantages of other fast disintegrating systems but also satisfy the unmet needs of the market. The present review focuses on benefits, formulation development, characterization and applications of orally fast disintegrating films.
Keywords: Oral disintegrating films, Casting method and Hydrophilic film former.
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