ANTIDIABETIC ACTIVITY OF BUTANOL FRACTION OF MURRAYA EXOTICA SEEDS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Kanakam Vijayabhaskar, Thummala Rajamani*, Mohammed Jaffer Sadik, Rohit Kumar and Hemanth Kyatham
ABSTRACT
The objective of the study was to evaluate the antidiabetic activity of butanol fraction of seed methanolic extract
on Murraya exotica; family Rutaceae in streptozotocin induced diabetic rats. By oral administration of extract
400mg/kg body weight for 15 days. The effect was compared with oral dose of 0.5mg/kg Glibenclamide. The
determination of blood glucose level by GOD-POD kit method. The result shows the butanol fraction on fasting
blood glucose level on 15th day of post induction (10 days of treatment) was 135.4±13.99 mg/dl compared to
fasting blood glucose of diabetic control animal 270.2±0.31mg/dl. The group treated with Glibenclamide 0.5
mg/kg showed fasting blood glucose level of 117.06±0.02* mg/dl. On 20th day of post induction (15days of
treatment), the seed butanol fraction treated group showed a fasting blood glucose level of 69.01±0.20 mg/dl,
compared to untreated diabetic animal which showed a fasting blood glucose level of 258.4±0.20mg/dl. The group
treated with Glibenclamide 0.5 mg/kg orally showed fasting blood glucose level of 68.06±0.21mg/dl the blood
glucose of hyperglycemic rats. From the toxicity study it was observed nontoxic upto 5g/kg body weight.
Keywords: Anti diabetic activity, Murraya exotica, butanol, methanol, streptozotocin, GOD-POD.
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