European Journal of Biomedical and Pharmaceutical Sciences

A RANDOMIZED STUDY TO COMPARE CLONIDINE AND ATENOLOL IN PROVIDING OPTIMAL SURGICAL FIELD IN NASAL SURGERIES UNDER GENERAL ANAESTHESIA

Amrinder Singh, *Anshul Singla, Ruchi Gupta, Tripat Bindra 

ABSTRACT

Aim: The present study was undertaken to evaluate the role of oral clonidine and atenolol in providing optimal surgical field in nasal surgeries under general anaesthesia. Material & Methods: 120 patients of ASA grade I & II posted for elective nasal surgeries were randomly divided into three groups of 30 each. Patients received 50mg oral atenolol in group A, 100 ug oral clonidine in group B and identical looking placebo tablets in group C two hours prior to surgery. Induction and maintainence of anaesthesia was performed by the same standard protocol. Heart rate, systolic and diastolic blood pressure were recorded during the intra-operative and post-operative period. The surgeon, blinded to group allocation, evaluated the quality of surgical field using a predefined Average Category Scale (ACS). The amount of total blood loss was also recorded. Results: The heart rate and blood pressure were within normal range from induction to the end of the surgery in the both groups A and B but was on higher side in group C. However the difference in blood loss between groups was highly significant being less in group B (117.77±7.59 ml) as compared to group A (155.73±14.90 ml) and group C (180.86±18.6). This resulted in a better surgical field in group B compared to group A and C. Conclusion: We conclude that oral clonidine is better than atenolol in providing optimal surgical field in nasal surgeries under general anaesthesia.

Keywords: atenolol, clonidine, nasal surgeries, blood loss.