European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND EVALUATION OF MICROPARTICLES CONTAINING SOTALOL HYDROCHLORIDE USING NATURAL POLYMERS FOR CONTROLLED RELEASE

*Nagendra R., Charan C. S., K. Hanumanthachar Joshi and Jayanthi C.

ABSTRACT

The present study aimed at preparation and Evaluation of microparticles for controlled release of Sotalol Hydrochloride using natural polymers in the treatment of Arrhythmia. Sotalol has both beta-adrenoreceptor blocking and cardiac action potential duration prolongation and antiarrhythmic properties. The microparticles of Sotalol Hydrochloride were prepared by ionic cross linking method. The prepared microparticles were evaluated for drug polymer compatibility, the results shown that there were no significant interactions. The encapsulation efficacy was ranging from 67-98%. The in-vitro drug release studies indicate the release of drug in a controlled manner over a period of 12 hrs. It was found that the Sotalol Hydrochloride release rate increased with a decreased amount of Guar gum since the drug is water soluble. This can be adjusted by maintaining the concentration of the natural polymers. The formulation F5 was found to be optimum formulation.

Keywords: Sotalol Hydrochloride, Arrhythmia, guar gum, Xanthan gum Controlled release.