Abstract
ASSOCIATION OF XENOBIOTIC GENETIC VARIANTS WITH OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS

Dr. R. Dhananjayan*

ABSTRACT

Xenobiotics are defined as any foreign substances or exogenous chemicals which the body does not recognize such as drugs, pollutants, as well as some food additives and cosmetics. The body removes xenobiotics by xenobiotic metabolism. This consists of the deactivation and the excretion of xenobiotic and happens mostly in the liver. Hepatic Microsomal Cytochrome P450 is a group of enzymes involve in xenobiotic metabolism. The increased oxidative stress is one of the main factors in the etiology and complications of Diabetes Mellitus. Three of the GST (glutathione-S-transferase) genes, GSTM1, GSTT1 and GSTP1 have been found to have functional polymorphisms that are frequently present in the general population. GSTM1 and GSTT1 polymorphisms are the most common polymorphisms of GST enzymes in the human population with major ethnic differences. In our study, among two xenobiotic genetic variants GSTT1 and GSTM1, no association of GSTT1 was found, but the variant GSTM1 was found to be risk in Type 2 Diabetes Mellitus.

Keywords: Xenobiotics, GST genes, Type 2 Diabetes Mellitus.


[Full Text Article]   [Download Certificate]

Indexing

Indexing

Best Article Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MARCH ISSUE PUBLISHED

    MARCH 2026 Issue has been successfully launched on 1 MARCH 2026.

  • EJBPS: New Impact Factor 2026

    EJBPS Impact Factor has been Increased from  7.482 to 8.181 for Year 2026.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     
Google Scholar Index Copernicus Indian Science Publications Urlich's Periodicals Directory, Proquest, UK (In Process) Research Bible, Fuchu, Tokyo. JAPAN UDLedge Science Citation Index International Society for Research activity (ISRA) Scientific Indexing Services (SIS) InfoBase Index (In Process) SJIF Impact Factor Scholar Article Impact Factor, SAIF Universal Impact Factor CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Global Impact Factor (GIF) (0.377) IP Indexing (IP Value 3.77) Web of Science Group (Under Process) Directory of Research Journals Indexing Scope Database Academia Academia Doi-Digital Online Identifier Doi-Digital Online Identifier ISSN National Centre Zenodo Indexing International CODEN Service, USA

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT