EXPANSION, ACTIVATION AND FUNCTION PROMOTION OF MYELOID-DERIVED SUPPRESSOR CELLS IN ADJUVANT-INDUCED ARTHRITIS
Sahar Sobhy Abd-Elhalem*
ABSTRACT
The role of myeloid-derived suppressor cells (MDSCs) in autoimmune diseases is starting to be elucidated. No previous studies demonstrate the role of these cells in adjuvant-induced arthritis (AA) rat model. MDSCs are one of the main cell populations that negatively regulate immune responses. Thus, MDSC targeting represents a promising tool to increase the efficacy of immune-based therapies. The objective of the present study was not only to investigate the role of myeloid-derived suppressor cells in AA rat model, but also to clarify the correlation between these cells and some factors which may promote their expansion, activation and suppressive activity. Body weight gain, white blood cells count, serum antinuclear autoantibodies, flow cytometry for MDSCs percentage in peripheral blood, serum IL-6, macrophage-colony stimulating factor (M-CSF), inducible nitric oxide synthase (iNOS) and arginase-1 were assessed in both control group and AA rat model supported by a histopathological study on joints. Results of the current study established for the first time the elevation of MDSCs percentage in AA rat model suggesting their possible potential role in the disease. Also, there is a positive correlation between increase in MDSCs percentage and elevated serum levels of IL-6, M-CSF, iNOS and arginase-1.
Keywords: Myeloid-Derived Suppressor Cells, Adjuvant-Induced Arthritis, IL-6, macrophage-colony stimulating factor.
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