CD117 IN DIFFERENTIATION ACUTE MYELOID LEUKEMIA AND ITS CO-EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA BY FLOW CYTOMETRY IN SUDANESE PATIENTS
Aadil Yousif*, Sherren Mallasi and Ihsan Faisl
ABSTRACT
The CD117 is a specific marker for diagnosis of acute myeloid leukemia (AML), also expressed in some acute lymphoblastic leukemia (ALL) cases. The aim of this study to classify AML and to differentiate the co-expression of CD117 in ALL by flow cytometry which used to detect the positive rate and expression level of CD117 in bone marrow mononuclear cells (BMMNCs), and peripheral blood (P.B). The results of the study showed that CD117 expression in 62% of AML while 00% in ALL. In addition, in AML sub group revealed that, M0 77%, M2 59%, M3 46%, M4 56%, M5 11%.M 61%, M7 10%. The study of mean intensity expression of CD117 among AML sub group (M0, M2, M3, M4, M6, and M7) were moderate expression (60%, 50%, 100%, 71.4%, 100%, and 100%) respectively, while (M5) were strong dim expression (100%). The expression of CD117 peak width among AML sub group the result showed that there was (M0) were heterogeneous and (M2, M3, M4, M5, M6, M7) were homogenous. The study concluded that CD117 expression is a specific and rather sensitive marker for differential diagnosis between AML and ALL.
Keywords: Acute Myeloid Leukemia, CD117, co-expression, Acute Lymphoblastic Leukemia.
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