PREPARATION AND VALIDATION OF ZINGIBER OFFICINALE CAPSULE AS CARDIAC SUPPLEMENT
Purohit A.D.,* Wanjari B.E., Khalode K.D. and Bhandarkar K.R.
ABSTRACT
Polyherbal formulation difficult to understand the theme of polyherbal preparation as a number of ingredients may vary from 2 to 25 or more. The Gargin capsule has been validated with modern tools and techniques of quality assurance for its quality, efficacy, stability and purity. Raw materials were evaluated as volatile matters, pH, loss on drying, residue on ignition, refractive index, alcohol soluble extractive and wt/ml were performed. The 6-Gingerol in Zingiber officinale oleoresin was found as 0.4283% and 6-gingerol in Gargin capsule was found as 0.02410%. The ruggedness of 6-gingerol was found as 0.9103 and 0.8946. The diallyl disulfide in garlic oil was found as 16.05% and diallyl disulfide in Gargin capsule was found as 2.6538%. The linearity study for diallyl disulfide was found in range of 545- 3270 mg/band by calculating standard calibration curve with linear equation y = 1.230x + 18.67 and regression coefficient R2 =0.999. The percentage recovery of diallyl disulfide was found in the range of 87.56% to 89.32%. All The value of % RSD was lower than 2% which indicates the accuracy of the method. There were no significant changes in the physical properties of capsule throughout the stability studies. The stability of capsules was studied by exposing it to elevated conditions of temperature and humidity. The HPTLC methods developed for 6-Gingerol and Diallyl disulfide are reproducible, sensitive, precise, specific and accurate and can be further applied for the routine quality control tests of this capsule.
Keywords: Gargin capsule, diallyl disulfide, oleoresin.
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