European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND CHARACTERIZATION OF TURNERY INCLUSION COMPLEX OF NAPROXEN ?-CYCLODEXTRIN AND POLYMER NUSLIN. (RESEARCH ARTICLE)

Swapnali Zore*, Akshay Shingate and Priyanka Beloshe

ABSTRACT

Naproxen suffers from poor solubility and thereby poor absorption, which ultimately leads to poor bioavailability. In present study, an attempt has been made to formulate and characterize Naproxen complex, using β-CD and polymer in order to enhance its solubility and dissolution rate. Phase solubility study was used to investigate the interaction of the drug in binary system as well as ternary system. It was observed that solubilization of Naproxen by β-CD was further enhanced by using Leucine. Several methods were used to prepare ternary complex of Naproxen – β-CD – Leucine. Ternary complex prepared by co-evapouration method containing Naproxen – β-CD – Leucine has shown the fastest dissolution rate as compared to pure Naproxen as well other methods were used to prepare complexes. The prepared ternary complex system was characterized by ction studies. Differential scanning calorimetry and scanning electron microscopy. It was observed that enhancement in solubility as well as dissolution rate of Naproxen was due to formation of ternary complex system.

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