European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF BETULA UTILIS BARK EXTRACT ON CAFETERIA DIET-INDUCED OBESITY IN RATS

Akhilnath V. S.*, Satish S. and A. R. Shabaraya

ABSTRACT

To evaluate the anti-obesity activity of Betula utilis bark against Cafeteria diet Induced obesity in rats. Materials and Methods: Obesity was induced in albino rats by feeding them a CD daily for 28 days, in addition to a normal diet. Body weight and food intake was measured initially and then every week thereafter. On day 28, the serum biochemical parameters were estimated and the animals were sacrificed with an overdose of ether. Orlistat was served as standard drug in the model. Evaluation of body weight, serum lipid profile and glucose level, liver weight and its TG level was carried out CD experimental model. Body temperature and locomotor activity was also evaluated. Results: Reported activity for the experimental models showed dose dependent significant anti-obesity activity for Betula utilis bark extract in terms of decrease in serum TG, TC, LDL-C, VLDL-C, liver TG and increased of serum HDL-C, locomotors activity in cafeteria diet induced obesity model rats. Body weight, liver weight and food intake also decreased. The result indicate that EBEB (200mg/kg) is more significant (P<0.05) than EBEB (100mg/kg) animals. Conclusion: In conclution, the findings of the study suggest that ethanolic bark extract of Betula utilis produces inhibitory effects on cafeteria diet-induced obesity in rats.

Keywords: Betula utilis, Antiobesity, Cafeteria diet.