Abstract
OPTIMIZATION OF QUINOLINE SYNTHESIS BY QUALITY BY DESIGN

Mrunali A. Bhongade*, Kumar Pratyush and Dr. Manjusha P. Yeole

ABSTRACT

Quinoline is one of the most important N-based heterocyclic aromatic compounds in the fields of medicinal and industrial chemistry, forming the scaffold for compounds of great significance. Quinoline recently is one of the priorities in lead selection by researchers because of its broad range of activities and also for their wide applications. These include anti-inflammatory and antitumor agents, the antimalarial drugs quinine and chloroquine, and organic light-emitting diodes. 6-Methoxy-8-aminoquinoline is a metabolite of primaquine belongs to 8-Amino Quinoline derivative which is used to treat malaria. The present article having focus on the optimization study of the synthesis of 6-Methoxy-8-nitroquinoline which is used in the synthesis of 6-Methoxy-8-aminoquinoline by QbD. The sulphuric acid and arsenic trioxide showed best results at 1200C for 4 hrs. The net percentage yield was found to be 27%. The novel method can be emitable for industrial applications.

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