FREQUENCIES OF ALLELIC VARIANTS OF THE CYP2D6: *4, *6 AND *10 IN QUILOMBOLA COMMUNITY, MARANHÃO, BRAZIL
Ilka Kassandra Pereira Belfort*, Marcelo dos Santos, Mauricio Avelar Fernandes and Sally Cristina Moutinho Monteiro
ABSTRACT
The formation of the Brazilian territory had as one of its fundamental characteristics, the miscegenation of several population matrixes. In this context, people from Africa played a fundamental role in shaping what is now Brazil. Brazil has the largest black population outside Africa and the second largest in the world, surpassed only by Nigeria. More than 40% of the Brazilian population corresponds to Afro-descendants. Genotyping of the CYP2D6 gene may serve as a predictive tool for the pharmacological effectiveness and / or toxicity of various drugs. However, due to the high cost of genetic testing, it is necessary to know the population frequencies in order to facilitate the development of clinical and laboratory strategies. Based on these, the present study aimed to verify the allelic and genotype frequencies of the *4, *6 and *10 variants of the CYP2D6 gene in a quilombola community, located in the municipality of Icatu, Maranhão, Brazil. The research was performed with 75 people, DNA samples were obtained and used for genotyping of polymorphisms, from April 2013 to April 2014. The results demonstrated the presence of genetic polymorphisms of CYP2D6 *4, *6 and *10 in the remaining population of quilombo. Detection of alleles that did not carry the studied mutations was observed in 65% of the individuals, followed by heterozygosis in 37% and homozygosis in 1%. The most prevalent polymorph was *6 with 81% of heterozygotes.
Keywords: CYP2D6; Polymorphism; Genetic Variability; Drug Metabolism; Pharmacogenetics.
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