THE ROLE OF HLA B27 IN THE TREATMENT RESPONSE, FUNCTIONAL LIMITATION AND DISEASE ACTIVITY IN ANKYLOSING SPONDYLITIS PATIENTS
Dina Omar, Mo Qian, Hasan A. M. M. Almansoub and Lingli Dong*
ABSTRACT
Objective: To assess the HLA B 27 impact on the treatment, disease activity and functional limitation of Ankylosing Spondylitis (AS) patients. Materials & Methods: 69 patients of both genders were enrolled in our study according to the ASAS criteria of Ankylosing Spondylitis. Demographic, clinical, disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), were compared regarding HLA-B27 status at baseline and after three months. They are investigating the role of HLA B27 in response to the treatment, functional impairment and clinical activity of the AS patients. Result: Data from 69 patients 52 male (73.2 %) were analyzed ,58 (81.7%) HLA B27 positive. HLA B27 positive group presented a statistically higher BASFAI score compared with a negative group at baseline. While there is no difference between both groups regarding the response to the treatment after three months nor the BASDAI and ASDAS scores. We also find the HLA B27 has not related to the age at the diagnosis. Conclusion: We found that the most crucial role of HLA B27 in AS patient is the prediction of more functional impairment to whom antigen is positive. while we did not find any evidence about a strong relationship between the antigen and the response of the patients to the treatment nor the activity of the disease.
Keywords: Ankylosing Spondylitis, HLA B27, BASDAI, BASFAI, ASDAS.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
