European Journal of Biomedical and Pharmaceutical Sciences

A STUDY OF CLINICO-BACTERIOLOGICAL-RADIOLOGICAL PROFILE OF PULMONARY TUBERCULOSIS IN DIABETIC PATIENTS WITH SPECIAL REFERENCE TO RIFAMPICIN RESISTANCE

Mehta Yatin, Agrawal Anurag, Tandon Rajeev, Singh Lalit and Agrawal Nipun*

ABSTRACT

Background: It was observed that patients who have DM complicated with TB often experience delayed sputum culture conversion, increased risk of death and recurrence. The emergence of MDR-TB makes the adverse anti-TB treatment outcomes in TB-DM comorbidity even worse, which may increase treatment related economic burden, promote the transmission of MDR-TB, and even accelerate the generation of extensively drug-resistant-TB (XDR-TB). Aim and Objectives: With the above background, the current study was planned to study the clinical profile, radiological presentation and the pattern of drug resistance of pulmonary tuberculosis in diabetics. Materials and Methods: The present prospective-observational study was conducted amongst the patients attending OPD and in the ward of Department of Pulmonary Medicine, SRMS IMS, Bareilly. A total of 60 patients of tuberculosis including both old and newly detected cases of diabetes were included in the study excluding extra-pulmonary tuberculosis, patients who developed transient hyperglycaemia on starting anti TB treatment and those who were not willing to participate. Result: Using the GenExpert kit, we found rifampicin resistance to be 8.33% in present study. Productive cough (73.3%), breathlessness (96.7%), chest pain (58.3%) and fever (71.7%) were the major presenting clinical features. On Chest X-ray, majority had unilateral involvement (81.7%). Infiltration (41.8%) and consolidation (31.7%) were the most common X-ray abnormalities. Conclusion: Present study and other contemporary studies from different parts of India indicate a high rifampicin resistance rate, thus indicating the need to address this problem.

Keywords: Tuberculosis, Diabetes, Rifampicin Resistance, GenExpert