European Journal of Biomedical and Pharmaceutical Sciences

PHARMACOGONSTICAL AND PHARMACEUTICAL ASSAY OF HARIDRADI VATI A FORMULATION FOR PREDIABETES

Siddhesh Waje*, Mandip Goyal, Harish C.R., V. J. Shukla and Nidhi Verma

ABSTRACT

Introduction: Standardization of Ayurvedic formulations is an important step for establishment of biological activity, consistent chemical profile, or quality assurance for production and manufacturing of herbal drugs. Haridradi Vati is an Ayurvedic polyherbal preparation comprising of Haridra (Curcuma longa L.), Daruharidra (Berberis aristata D.C.), Kutaja (Holarrhena antidysenterica (L.) Wall.), Vacha (Acorus calamus Linn.), Musta (Cyperus rotundus Linn), Devadaru (Cedrus deodara Roxb), Shunthi (Zingiber officinale Rosc) and Haritaki (Terminalia chebula Retz.). The early stage of type-2 diabetes is known as prediabetes. Prameha Purvarupavastha can be correlated with earlier stage of diabetes i.e. prediabetes.[1] Haridradi vati may help to reverse prameha purvarupavastha (prediabetes).In the present study, an attempt has been made to develop pharmacognostical and pharmaceutical standards for Haridradi vati. Aims: To evaluate pharmacognostical and physico-chemical characters of Haridradi vati Materials and Methods: The ingredients of Haridradi Vati were collected from the Pharmacy of Gujarat Ayurved University (GAU) Jamnagar district, Gujarat and pharmacognostical analysis of Haridradi Vati like organoleptic characteristics and micro pictographs were done. Pharmaceutical analysis of the drug included parameters like water and alcohol soluble extract , pH, total ash and loss on drying along with HPTLC Results: The pharmacognostical analysis of Haridradi Vati showed the presence of sclerides of Daruharidra, starch grain of Musta, fibers of Shunthi, starch grain of Kutaj, pittet stone of Haritaki, oleoresin of Haridra, oil globulin of Vacha. Physiochemical analysis of Haridradi Vati revealed weight variation of 28%, hardness1.6 kg/cm2, disintrigation time > 1 hr. etc., In HPTLC Haridradi Vati revealed 5 spots at 254 nm and 4 spots 366 nm. Discussion: Pharmacognostical study helps in exact authentication of ingredients present in formulation through its organoleptic characters like taste, odor, color and touch along with microscopical characters and physico-chemical parameters. The presence of all contents of raw drugs in the final product shows the genuinity of the final product. All the pharmaceutical parameters analyzed showed values permissible for the Vati. Conclusion: As there are no reported study on the Haridradi Vati, the findings of the study will be useful in the standardization of the drug and study might help as reference guidance for future scientific evaluations of the drug.

Keywords: Haridradi Vati, pharmacognosy, physicochemical analysis, prediabetes.