European Journal of Biomedical and Pharmaceutical Sciences

ESTIMATION OF BIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS ALTERATION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME IN BASRAH GOVERNORATE

Dalal F. Al-Akabi*, Faris S. Kata and Edwar Z. Khosho

ABSTRACT

Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorder in a reproductive age women around the world. Because of a large number of women infected with PCOS in Basrah city, the present study has been designed to underline some of the causes of PCOS through the changes in biochemical, and immunological parameters. This study was done in basrah governorate since May, 2018 until November, which includes 150 females divided in to two equal groups, PCOS patients and healthy women as control in basrah city. The results showed that AST, ALP, urea, cholesterol, LDL-C, total protein and glucose were significantly increased in PCOS patients than control group (p<0.05), while HDL-C was significantly decreased in PCOS patients than control group(p<0.05), even ALT, TG and VLDL recorded high levels in PCOS patients than control but the difference is not significant (p>0.05). Also our study recorded a significant increased in the level of immunological parameters (TNF- α and IL-18) in PCOS patients than control group(p<0.05). In conclusion the metabolic abnormalities are prevalence in PCOS patients and PCOS may induce the inflammation characterize in these women, also these abnormalities might be involved in the development of PCOS.

Keywords: polycystic ovary syndrome/ PCOS / Total protein/ glucose/ IL-18/ TNF-?.