Abstract
EVALUATION OF C3 COMPLEMENT AND INFLAMMATORY MARKER (C-REACTIVE PROTEIN) IN TYPE 2 DIABETES SUBJECTS WITH INSULIN RESISTANCE

Iruegbukpe F.*, Davis T. & Ibegbulem E. O.

ABSTRACT

Type 2 Diabetes can be caused by Insulin Resistance, a condition in which cells fail to respond to insulin properly and can progressively leads to lack of insulin. Insulin Resistance is directly interlinked with various inflammatory responses. The significance of this study is to evaluate C3 Complement and Inflammatory marker (CRP) in Type 2 Diabetes mellitus with insulin resistance in Yenagoa, Bayelsa state. 220 subjects were recruited into the study work, 100 constitute T2Dm with insulin resistance, 60 T2Dm with no insulin resistance while the remaining 60 were normoglycemic with no insulin resistance. Insulin Resistance was assessed for using anthropometric measurements (hypertensive, hyperglycemia, hypertriglyceridemia, hypercholesterolemia and TG/HDL ratio˃2). Result of the analysis showed a significant difference (p˂0.05) in C3 Complement and CRP values obtained in the studied population. The mean±SD of complement C3 in T2DM with insulin resistance was (235.01 ± 52.67) mg/dl and was (214.82 ± 51.68) mg/dlin T2DM with no IR, while the control gave (160.98 ± 47.89) mg/dl respectively. When compared between groups, there was no significant difference observed. Hs-CRP in T2DM with IR gave a mean ± SD of (5.97 ± 2.89) mg/l, T2DM with no IR gave (2.57 ± 1.77a) mg/l while the control gave a mean ± SD of (4.59 ± 2.70ab) mg/l respectively. When compared between groups, there was a significant difference observed. Sex and age showed no significant difference in the studied biochemical parameters. Correlation between C3 Complement and Hs-CRP showed a significant difference. Conclusively, this study contributes to knowledge and evidences that Hs-CRP and C3 can be assayed as routine test in individuals suspected of having Insulin Resistance because they tend to have a strong association with T2Dm.

Keywords: c3 complement, inflammatory marker, C - reactive protein, type 2 diabetes, insulin resistance.


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