Abstract
THE EFFECT OF SITAGLIPTIN AND MIRABEGRON ON SERUM LEPTIN, ADIPONECTIN, TUMOR NECROSIS FACTOR-? AND OXIDATIVE STRESS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Mohamed M. Elbadr* and Mona Sedeek

ABSTRACT

Introduction: Mirabegron is a novel beta-3 receptor agonist. It has potential antiobesity and antidiabetic effects. The aim of the study was the evaluation of the possible antidiabetic, anti-inflammatory and antioxidant effects of mirabegron as well as its effect on serum leptin and adiponectin in diabetic rats alone and in combination with sitagliptin. Materials and Methods: Five groups of Wistar rats were used. Diabetes was induced in group 2, 3, 4 and 5 using streptozotocin in dose of 100 mg/kg. The third, fourth and fifth group were treated for 20 days with sitagliptin (10 mg/kg), mirabegron (10 mg/kg) and combination of the 2 drugs, respectively. Blood samples were used for determination of blood glucose, serum level of leptin, adiponectin, TNF-α, malondialdehyde (MDA) and glutathione (GSH). Results: Streptozotocin caused induction of type-2 diabetes, increased TNF-α and MDA with reduction in the leptin, adiponectin and GSH. Sitagliptin caused a significant reduction of blood glucose, TNF-α and MDA with significant increase in leptin, adiponectin and GSH. Mirabegron caused a non-significant reduction of blood glucose, TNF-α and MDA with significant increase in the leptin and GSH. There was non-significant difference between the effect of the combination of sitagliptin and mirabegron and the effect of sitagliptin alone. Conclusion: Sitagliptin has a moderate anti-inflammatory and antioxidant effects. Mirabegron has a modest antidiabetic, anti-inflammatory and antioxidant effects and failed to normalize the low serum levels of leptin and adiponectin of streptozotocin induced diabetic rats. The addition of mirabegron to sitagliptin shows no additional or synergistic effects.

Keywords: Adiponectin; Leptin; Mirabegron; Sitagliptin; Streptozotocin.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tanima Debnath Sarkar

Download Article : Click here

News & Updation

  • EJBPS: OCTOBER ISSUE PUBLISHED

    OCTOBER 2021 Issue has been successfully launched on 1 October 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT