Abstract
COLISTIN RESISTANCE GRAM NEGATIVE BACTERIA FROM TRACHEAL ASPIRATES AMONG PATIENTS ADMITTED IN INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL, BANGLADESH

*Dr. Abu Naser Ibne Sattar and Dr. Sanjida Khondakar Setu

ABSTRACT

Background: Multidrug-resistant (MDR) Gram negative bacteria (GNB) poses a serious therapeutic problem as no development of newer antimicrobials. In most cases, colistin remains the last viable effective option which leads to an increase exposure of patients to colistin resulting the growing threat of colistin resistance. Objective: The aim of this study was to observe antibiotic susceptibility pattern and prevalence of colistin resistance among gram negative bacteria from tracheal aspirates among patients admitted in ICU of a tertiary care hospital. Materials and Methods: A total of 160 specimens of tracheal aspirates collected from ICU patients were cultured on appropriate media in the department of microbiology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh. Then standard biochemical tests were done to identify the isolated organism. Antibiotic susceptibility profile of isolated bacteria was studied to detect their resistant pattern against colistin. Results: Acinetobacter spp. was the predominant organism (40.59%) found in tracheal aspirate. Among the isolated gram negative bacteris 10.7% were found resistant to colistin. Conclusion: The distribution of colistin resistance pattern in the study is quite unnerving. Producing a local antibiogram database will improve the knowledge of antimicrobial resistance pattern in ICU and will also help to improve treatment strategies.

Keywords: Colistin, intensive care unit, tracheal aspirates, gram negative bacteria, antibiotic susceptibility pattern, Acinetobacter spp.


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