Abstract
COMPARATIVE IN-VITRO EVALUATION OF SOME COMMERCIAL BRANDS OF METFORMIN TABLETS MARKETED IN TRIPOLI-LIBYA

Tamader Y. Elghnimi*, Wejdan Bzezi, Mohamed M. Siaan, Wesal N. Elgreew and Hadeel M. Benmansour

ABSTRACT

The availability of several brands of Metformin tablets in Libyan pharmacies today places health practitioners in a problem of generic substitution. The aim of the present study was the evaluation and comparison between six different Metformin 500 mg brands, which are commercially available in the Libyan market produced by various pharmaceutical companies with different trade names. The physicochemical equivalence of six brands of Metformin tablets were investigated through the evaluation of both official and non-official standards according to the British Pharmacopoeia including uniformity of weight, thickness, hardness, disintegration time, drug content as well as dissolution rate. Acceptable external features as well as uniformity in diameter and thickness revealed for all the tablets. The entire brands complied with the official specifications for uniformity of weight where no tablet showed a deviation more than ±5%. Brands B, C, F had the highest crushing strength and highest disintegration time compared to the other brands. All the Six brands could be regarded as bioequivalent and therefore can be interchanged in the clinical practice. This sort of study is good indicator for the evaluation of the idealness of commercial products.

Keywords: Metformin, physicochemical properties, evaluation, bioequivalence.


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