QUINAZOLINE-CHALCONE HYBRID: DIFFERENT SYNTHETIC SCHEMES AND BIOLOGICAL ACTIVITIES –A REVIEW
Priyanka Bobde*, L. A. Kawale and Darshana Patil
ABSTRACT
Quinazolines are important class of six membered heterocyclic compounds: are widely found as the core scaffold
in a large variety of compounds that possess important biological activities like anti-inflammatory,
antihypertensive, anticancer, anticonvulsant, antibacterial, antitubercular, antifungal, antiviral, antidepressant,
antidiabetic and analgesic. On other hand chalcone is part of flavonoids and isoflavonoids. Chemically it is 1,3
diaryl-2-propan-1-one. It is made up of two aromatic ring joined together by three carbon bridge having carbonyl
moiety and α, β unsaturation. Chalcone are synthesized by Claisen Schmidt condensation of aldehyde and ketone
in equimolar concentration. It has various biological activities like antibacterial, antifungal, anti-inflammatory,
antihyperglycemic, anti-HIV and anticancer. Quinazoline-chalcone hybrids show potent biological activities and
solve drug resistance problem. Also avoid combinational therapy. The present review focus on the different
schemes of synthesis and biological activities of quinazoline-chalcone hybrid.
Keywords: Quinazoline-chalcone hybrid, Claisen-Schmidt condensation, heterocyclic compound, anticancer, CNS-activity, antimicrobial activity.
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