European Journal of Biomedical and Pharmaceutical Sciences

UNDERSTANDING THE PREVALENCE OF DEPRESSION IN PREGNANT WOMEN WITH GESTATIONAL DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PROFILE

Dr. Amitabh Saha*, Aditya Rana, Dr. V. V. Gantait

ABSTRACT

Introduction: Previous literature suggest that there exists a bi-directional relationship between diabetes and depression. But the evidence about the prevalence of depression in pregnant women with gestational diabetes mellitus in India and its co-relation with the sugar laboratory profile and anthropometrics is scanty. Objectives: To study the prevalence and association of depression during pregnancy with GDM, and to analyse and associate the metabolic parameters like BMI, Glucose tolerance and BP with depression in GDM patients. Methodology-In this cross-sectional analytical study, done at the obstetrics OPD of a hospital, on 347 antenatal cases(gestational age > 24 weeks), sociodemographic details, BP, BMI, Blood Sugar(OGTT) were measured. For depression status’s assessment, CUDOS(Clinically Useful Depression Outcome Scale)Questionnaire used. Data analyzed by SPSS 23. Results-In our study, significant difference was found in prevalence of depression in GDM patients(56.07%) and Non-GDM Sub-group(38.5%).And GDM subgroup had more number of women with mild and moderate depression. Mean Depression Score was 14.7 and 9.5 in GDM and Non-GDM groups, respectively. Also, Depression and GDM were found to be significantly associated. GDM group was found to have more mean age(GDM with depression=27.5 and Non-GDM without depression=24.9). Also, GDM aged more than 30 were more prone to develop depression. GDM women with depression had more mean BMI(27.14) vs. GDM without depression(25.03). BMI was significantly associated with the depression in the GDM population. Mean OGTT values were higher among the women who had depression and the difference was significant for the 1hr and 2hr blood glucose sample.We found that there is a significant association betweenthe deranged OGTT valuesabove diagnostic cutoff of GDM and the depressionamong GDM population. GDMsub-group chiefly consisted of women with middle and highsocio-economic group. Conclusion- Early screening for depression in GDM patients must be done, to manage the diabetes well and prevent the development of complications. As this will prove beneficial for the physiological and psychological condition of the patient.

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