Abstract
DEVELOPMENT AND OPTIMIZATION OF SUSTAINED RELEASE ABACAVIR MATRIX TABLETS

*B. Premkumar, K. Bindhumadhavi, K. P. Chandralekha, Makam Sirisha, A. Srinivasa Rao

ABSTRACT

The aim of the present study was to develop and characterize Abacavir sustained release tablets. These Abacavir solid unit dosage forms were prepared by using direct compression technique and by utilizing synthetic polymers such as ethyl cellulose, eudragit and sodium alginate. Abacavir drug is used in the treatment of human immunodeficiency virus (HIV) infection. It is nucleoside reverse transcriptase inhibitors (NRTIs). The prepared tablets were characterized for hardness, thickness, disintegration time and drug release studies. Optimized formulation of drug delivery was 98.70% in 8 hours along with satisfactory results. It was noted that A5 formulation was the best formulation compared with the other formulations based on the drug release studies and physical parameters.

Keywords: Abacavir, Hydroxypropyl methyl cellulose, sodium alginate, direct compression technique, in- vitro drug release studies.


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