Abstract
A RESEARCH ON EVALUATION OF ANTIANXIETY ACTIVITY OF PUMPKIN (CUCURBITA MAXIMA) SEEDS IN MICE

Saisree P. M.*, Karunakar Hegde and A. R. Shabaraya

ABSTRACT

This study was performed to investigate the anxiolytic effects of aqueous extract of Cucurbita maxima seeds (AECM) in mice using the elevated plus-maze model (EPM) and light dark model. The extract administered orally in two different doses of 100mg/kg and 200mg/kg, were able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze, also increases the time spent by mice in the illuminated side of the light–dark test, in comparison with control animals. This effect was comparable to that of the diazepam (1.0mg/kg i.p.). These results indicate that AECM is an effective anxiolytic agent.

Keywords: Cucurbita maxima, EPM, AECM.


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