European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW: MICROPELLETS AN APPROACH TOWARDS NOVEL DRUG DELIVERY

Swati Chaudhary*, Ashutosh Badola, Sweta Baluni, Monika Bhatt, Somya Sah

ABSTRACT

Pharmaceutical pellets are isometric aggregates with smooth surfaces and narrow particle size distribution. Nowadays, the mean pellet size ranges from 300 μm to 3 mm. besides the shape, they also have low porosity and high mechanical stability. due to the roundness and closed shape of the particles, the flowability of pellets is excellent. Micropellets show a number of additional favourable properties. The most important of which is the larger specific surface area, which results in faster dissolution rates. Micropellets can be used in a number of dosage forms that may be beneficial for certain patient groups. Micropellets and regular pellets are usually processed into tablets or filled into capsules. Further investigations are underway to use micropellets as solid drops in a „sprinkle capsule‟ or in a „dose sipping technology‟ (dst). These application forms are especially suitable for patients who have problems swallowing drug products and therefore refuse to take medicine at all (e.g. paediatric or elderly patients).[6]

Keywords: Micropellets, Pharmaceutical pellets.