Abstract
FORMULATION AND EVALUATION OF FELODIPINE HOLLOW MICROSPHERES

*B. Premkumar, Makam Sirisha, K. P. Chandralekha, K. Bindhumadhavi, P. Rajeshkumar, A. Srinivasa Rao

ABSTRACT

Felodipine is a calcium channel blocker which is used for the treatment of high blood pressure to prevent heart stroke. In the current research work hollow microspheres of Felodipine with better absorption in gastric pH was formulated by using various polymers. Drug polymer compatibility was characterized by FT-IR. Microspheres were prepared by emulsion solvent diffusion technique by using different polymers such as ethyl cellulose, carbopol 934, eudragit and sodium alginate at varying concentrations. The formulations were evaluated for micromeritic properties, buoyancy, percentage yield, entrapment efficiency, in vitro studies and stability stuides. SEM photographs showed outer surface of microspheres was smooth and dense where as internal surface was porous which helped to prolong floating. Optimized F2 formulation exhibited higher release rate 95.55%. In vitro drug release studies showed controlled release of Felodipine for over 8h. Stability studies indicated the F2 formulation was stable with respect to its drug release.

Keywords: Felodipine hollow microspheres, polymers, emulsion solvent diffusion technique, FTIR Studies, floating time, in vitro drug release studies.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tanima Debnath Sarkar

Download Article : Click here

News & Updation

  • EJBPS: OCTOBER ISSUE PUBLISHED

    OCTOBER 2021 Issue has been successfully launched on 1 October 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT