European Journal of Biomedical and Pharmaceutical Sciences

THE ASSOCIATION OF PLASMA CERULOPLASMIN AND C-REACTIVE PROTEIN WITH TYPE2 DIABETES MELLITUS IN SUDANESE PATIENTS IN KHARTOUM STATE

Abubakr H. Khougali*, Abdelwhab Abdien, Haghamad Allzain, K.H. Bakheit and Salman Taha Ahmed

ABSTRACT

Background: The inflammatory markers cytokine C- reactive protein (CRP) and Ceruloplasmin are involved in multiple metabolic pathways, including insulin regulation, reactive oxygen species, lipoprotein lipase action and adipocytes function. Objectives: The study intended to examine the association of plasma C-reactive protein and Ceruloplasmin with type2 diabetes mellitus in Sudanese patients in Khartoum State. Study design: It was a descriptive, case control study, included fifty (50) participants, thirty (30) of them were patients with type2 diabetes mellitus and twenty (20) were healthy control group. It had been conducted in Khartoum State from March to July 2018. Results: The study found that the means of random blood glucose, plasma Ceruloplasmin and C-reactive protein were (284.97±74.87, 76.30±8.56, 35.76±29.92) and (118.35±14.96, 35.80±7.74, 2.80±0.755) in case and control group respectively with highly significant P value of 0.000. Conclusion: Plasma C-reactive protein and Ceruloplasmin levels were high in type2 diabetes mellitus patients. There was significant effect of disease duration on plasma Ceruloplasmin level where as no significant effect of disease duration on plasma CRP levels was observed.

Keywords: Type2 diabetes mellitus, C-reactive protein , Ceruloplasmin.